Even though cancer is now viewed as a stem cell disease, there is still no consensus on the metabolic characteristics of these cells. This review by Maria Peiris-Pagès et al. summarizes the latest findings and discoveries on cancer stem cell metabolism.
Nikiana Simigdala et al. report data that provide support for the role of cholesterol biosynthesis enzymes and the cholesterol metabolites, 25-HC and 27-HC, in a novel mechanism of resistance to endocrine therapy in estrogen receptor-positive breast cancer that has potential as a therapeutic target.
We are pleased to announce the winners of the Breast Cancer Research Image Competition, run in partnership with the UK's largest breast cancer charity, Breast Cancer Now. Congratulations to Victoria Cookson, Post Doctoral Research Associate at the University of Sheffield, UK who was the Immunofluorescence and overall winner with a spheroid generated from a 3D culture of fluorescently labelled MDA-MB-231 breast cancer cells. Congratulations also to the 3 category winners: Sarah Boyle, Edward P Carter and James C McConnell.
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