| Dear Dr Wirawan,
We are pleased to share with you the BMC Medicine February content update, featuring journal news, top articles and our most recent table of contents. Featured Article A population-based observational study aimed to elucidate the trends and factors linked with dying in hospital in those with chronic obstructive pulmonary disease (COPD) and interstitial pulmonary diseases (IPD), and the effectiveness of a national end of life care (EoLC) strategy in reducing hospital deaths. Over a 14-year follow-up, hospital deaths declined, however, patients with multimorbidity benefited less. Early implementation of EoLC strategies should be enhanced, and area deprivation and patient demographics should also be taken into account. From the BMC Medicine blog Following a successful kick-off on the 4th February 2016, World Cancer Day 2016-2018 continues this year under the hash tag #WeCanICan with the aim to encourage all of us to "do our part to reduce the global burden of cancer". BMC Medicine Assistant Editor Paulina Szyszka continues highlighting the key findings in cancer research reported over the past 12 months in an annual blog (see last year's here). Table of Contents Commentary Minireview Opinion Research What is the association of hypothyroidism with risks of cardiovascular events and mortality? A meta-analysis of 55 cohort studies involving 1,898,314 participants | Yu Ning, Yun J. Cheng, Li J. Liu, Jaskanwal D. S. Sara, Zhi Y. Cao, Wei P. Zheng, Tian S. Zhang, Hui J. Han, Zhen Y. Yang, Yi Zhang, Fei L. Wang, Rui Y. Pan, Jie L. Huang, Ling L. Wu, Ming Zhang and Yong X. Wei | BMC Medicine 2017 15:21 | Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort | Renée T. Fortner, Danja Sarink, Helena Schock, Theron Johnson, Anne Tjønneland, Anja Olsen, Kim Overvad, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Heiner Boeing, Antonia Trichopoulou… | BMC Medicine 2017 15:26 | The effect of an antenatal lifestyle intervention in overweight and obese women on circulating cardiometabolic and inflammatory biomarkers: secondary analyses from the LIMIT randomised trial | Lisa J. Moran, Louise M. Fraser, Tulika Sundernathan, Andrea R. Deussen, Jennie Louise, Lisa N. Yelland, Rosalie M. Grivell, Anne Macpherson, Matthew W. Gillman, Jeffrey S. Robinson, Julie A. Owens, Jodie M. Dodd | BMC Medicine 2017 15:32 | Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects | Cajsa Davegårdh, Christa Broholm, Alexander Perfilyev, Tora Henriksen, Sonia García-Calzón, Lone Peijs, Ninna Schiøler Hansen, Petr Volkov, Rasmus Kjøbsted, Jørgen F. P. Wojtaszewski, Maria Pedersen… | BMC Medicine 2017 15:39 | Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach | Amélie Bonnefond, Loïc Yengo, Aurélie Dechaume, Mickaël Canouil, Maxime Castelain, Estelle Roger, Frédéric Allegaert, Robert Caiazzo, Violeta Raverdy, Marie Pigeyre, Abdelilah Arredouani, Jean-Michel Borys… | BMC Medicine 2017 15:37 | Review Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer's disease | Branko Malojcic, Panteleimon Giannakopoulos, Farzaneh A. Sorond, Elsa Azevedo, Marina Diomedi, Janja Pretnar Oblak, Nicola Carraro, Marina Boban, Laszlo Olah, Stephan J. Schreiber, Aleksandra Pavlovic… | BMC Medicine 2017 15:27 | Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects | Ilaria Di Donato, Silvia Bianchi, Nicola De Stefano, Martin Dichgans, Maria Teresa Dotti, Marco Duering, Eric Jouvent, Amos D. Korczyn, Saskia A. J. Lesnik-Oberstein, Alessandro Malandrini, Hugh S. Markus… | BMC Medicine 2017 15:41 | Benefits of publishing with us • | 2016 median turnover times: initial decision three days; first decision after peer review 40 days | • | Portable peer review | • | Broad medical readership | Follow @BMCMedicine on Twitter | | | |