| Dear Dr Wirawan, Genome Biology's special collection on cancer progression and heterogeneity, guest edited by Professor Elaine R. Mardis and Professor Samuel Aparicio, has now been published. In the collection, we present over 20 primary research articles providing insights into between-patient and within-patient heterogeneity in cancer, the processes that lead to cancer progression, and mechanisms of therapy response and resistance.  | Additionally, the collection includes specially commissioned articles, which take the reader from the challenges of translating cancer genomics, through an overview of the current state of the field of personalized genomics in the context of cancer heterogeneity, to the latest advances in diagnostic methods. These articles are written by the leaders in the field, including Charles Swanton, Anne-Lise Børresen-Dale, Carlo Croce, Alberto Bardelli and many others. |
| A selection of some of the collection articles: | Editorial
Tumor heterogeneity: next-generation sequencing enhances the view from the pathologist's microscope
Samuel Aparicio and Elaine Mardis
Abstract | Full Text | PDF | Opinion
The multitude of molecular analyses in cancer: the opening of Pandora's box
Hege G Russnes, Per E Lønning, Anne-Lise Børresen-Dale, Ole C Lingjærde
Abstract | Full Text | PDF | Opinion
Toward better benchmarking: challenge-based methods assessment in cancer genomics
Paul C. Boutros, Adam A. Margolin, Joshua M. Stuart, Andrea Califano, Gustavo Stolovitzky
Abstract | Full Text | PDF | Research
Genome-driven integrated classification of breast cancer validated in over 7,500 samples
Hamid R Ali, Oscar M Rueda, Suet-Feung Chin, Christina Curtis, Mark Dunning, Samuel AJR Aparicio, Carlos Caldas
Abstract | Full Text | PDF | Research
Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions
Angela R Brannon, Efsevia Vakiani, Brooke E Sylvester, Sasinya N Scott, Gregory McDermott, Ronak H Shah, Krishan Kania, Agnes Viale, Dayna M Oschwald, Vladimir Vacic, Anne-Katrin Emde, Andrea Cercek, Rona Yaeger, Nancy E Kemeny, Leonard B Saltz, Jinru Shia, Michael I D'Angelica, Martin R Weiser, David B Solit and Michael F Berger
Abstract | Full Text | PDF | Method
Unraveling the clonal hierarchy of somatic genomic aberrations
Davide Prandi, Sylvan C Baca, Alessandro Romanel, Christopher E Barbieri, Juan Miguel Mosquera, Jacqueline Fontugne, Himisha Beltran, Andrea A Sboner, Levi A Garraway, Mark A Rubin, Francesca Demichelis
Abstract | Full Text | PDF | Access the full special collection here. Alongside open access research, Genome Biology publishes expert reviews and commentaries, which are available via subscription. Take advantage of our 30-day free trial subscription to access the high-quality commissioned content in this special collection. For more information about Genome Biology please visit our website, or, contact the editorial office. With best wishes, Rafal Marszalek, PhD
Special Issue Editor and Louisa Flintoft, PhD
Deputy Editor
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