Immune checkpoint inhibitors have proven to be viable therapeutic options for advanced non-small cell lung cancer (NSCLC) resistant to the standard chemotherapy with platinum-based compounds. Success in the second-line setting has encouraged evaluation of immunotherapeutics as the first-line treatment. Jordi Remon, Benjamin Besse and Jean-Charles Soria discuss contradictory results of recent phase III trials assessing first-line immunotherapy in NSCLC, looking at reasons for discrepancy and remaining open questions.
Attention disorders are prevalent in 5% of the total population and are commonly diagnosed on the basis of a patient's clinical history and an examination aided by symptom check sheets. A new study published in BMC Medicine finds that EEGs (electroencephalograms) can reliably detect specific brain differences associated with attentional disorders that are not observed in control subjects. Here to tell us more is lead author of the study, Frank Duffy.
Over the past few decades the concept and application of self management of asthma have evolved, reducing both emergency service use and the day to day symptoms of asthma. In this blog, authors of a new review in BMC Medicine, talk us through the history of self management and the positive evidence supporting it.
With the abundance of new findings on the effects of various foods on our health, how shall we select the best quality evidence and recommendations to follow? Here, we summarize recent studies published in BMC Medicine, which provide evidence on the effects of various nutritional modifications on health outcomes.
Xinyi Lin, Ives Yubin Lim, Yonghui Wu, Ai Ling Teh, Li Chen, Izzuddin M. Aris, Shu E. Soh, Mya Thway Tint, Julia L. MacIsaac, Alexander M. Morin, Fabian Yap, Kok Hian Tan, Seang Mei Saw, Michael S. Kobor… BMC Medicine 2017 15:50
G. Michael Allan, Caitlin R. Finley, James McCormack, Vivek Kumar, Simon Kwong, Emelie Braschi, Christina Korownyk, Michael R. Kolber, Adriennne J. Lindblad, Oksana Babenko and Scott Garrison BMC Medicine 2017 15:58
Dimitrios Korbakis, Christina Schiza, Davor Brinc, Antoninus Soosaipillai, Theano D. Karakosta, Christine Légaré, Robert Sullivan, Brendan Mullen, Keith Jarvi, Eleftherios P. Diamandis and Andrei P. Drabovich BMC Medicine 2017 15:60
Rob Riemsma, Suzanne Hagen, Ruth Kirschner-Hermanns, Christine Norton, Helle Wijk, Karl-Erik Andersson, Christopher Chapple, Julian Spinks, Adrian Wagg, Edward Hutt, Kate Misso, Sohan Deshpande… BMC Medicine 2017 15:63
Thomas M. Gill, Daniel P. Beavers, Jack M. Guralnik, Marco Pahor, Roger A. Fielding, Michelle Hauser, Todd M. Manini, Anthony P. Marsh, Mary M. McDermott, Anne B. Newman, Heather G. Allore & Michael E. Miller BMC Medicine 2017 15:65
Shakila Thangaratinam, John Allotey, Nadine Marlin, Julie Dodds, Fiona Cheong-See, Peter von Dadelszen, Wessel Ganzevoort, Joost Akkermans, Sally Kerry, Ben W. Mol, Karl G.M. Moons, Richard D. Riley & Khalid S. Khan BMC Medicine 2017 15:68