A systematic review on anti-obesity drugs, reveals that 25 have been withdrawn between 1964 and 2009 due to adverse reactions. In particular, most of the drugs affecting monoamine neurotransmitters have been withdrawn because of adverse reactions, which highlights the need for more careful assessment before anti-obesity drugs are approved.
Published in BMC Medicine, a new collaborative study reports on the prevalence of tuberculosis drug resistance in West Africa, a previous white spot in our drug resistance knowledge. Here, three of the study's authors tell us about the challenges and achievements of one of the largest West African collaborations to date.
Since its launch in July this year, BMC Medicine's article collection on Translational Oncology has attracted interesting research articles. Here, we present a brief overview of the most recent publications on adoptive immunotherapy for bladder cancer, tumor-associated macrophages in classical Hodgkin lymphoma, correlating tumor mutation load with immunotherapy outcomes and spatial transcriptome analysis of glioblastoma.
Tumor heterogeneity is observed at many levels: from cancer subclones in primary tumor with distinct characteristics to differences between primary and metastatic tumors in the same individual. As it affects treatment response, it is one of the key challenges in effective cancer management in the clinical practice. Here, co-authors of an article published in BMC Medicine discuss their study of kidney cancer patients.
Howard J. Aizenstein, Andrius Baskys, Maura Boldrini, Meryl A. Butters, Breno S. Diniz, Manoj Kumar Jaiswal, Kurt A. Jellinger, Lev S. Kruglov, Ivan A. Meshandin, Milija D. Mijajlovic, Guenter Niklewski, Sarah Pospos... BMC Medicine 2016, 14:161
João Pedro Ferreira, Nicolas Girerd, Pierpaolo Pellicori, Kevin Duarte, Sophie Girerd, Marc A. Pfeffer, John J. V. McMurray, Bertram Pitt, Kenneth Dickstein, Lotte Jacobs, Jan A. Staessen, Javed Butler, Roberto Latini, Serge Masson... BMC Medicine 2016, 14:181
Joanne M. de Laat, Rob B. van der Luijt, Carolina R. C. Pieterman, Maria P. Oostveen, Ad R. Hermus, Olaf M. Dekkers, Wouter W. de Herder, Anouk N. van der Horst-Schrivers, Madeleine L. Drent, Peter H. Bisschop... BMC Medicine 2016, 14:182
Brendon Stubbs, Ai Koyanagi, Nicola Veronese, Davy Vancampfort, Marco Solmi, Fiona Gaughran, André F. Carvalho, John Lally, Alex J. Mitchell, James Mugisha and Christoph U. Correll BMC Medicine 2016, 14:189
Sally Hopewell, Isabelle Boutron, Douglas G. Altman, Ginny Barbour, David Moher, Victor Montori, David Schriger, Jonathan Cook, Stephen Gerry, Omar Omar, Peter Dutton, Corran Roberts, Eleni Frangou, Lei Clifton... BMC Medicine 2016, 14:199