| | Dear Dr Wirawan,
We are pleased to share with you our November content update, featuring journal news, top articles and our most recent table of contents.
Featured Article A systematic review on anti-obesity drugs, reveals that 25 have been withdrawn between 1964 and 2009 due to adverse reactions. In particular, most of the drugs affecting monoamine neurotransmitters have been withdrawn because of adverse reactions, which highlights the need for more careful assessment before anti-obesity drugs are approved.
From the BMC Medicine Blog Published in BMC Medicine, a new collaborative study reports on the prevalence of tuberculosis drug resistance in West Africa, a previous white spot in our drug resistance knowledge. Here, three of the study's authors tell us about the challenges and achievements of one of the largest West African collaborations to date.
Since its launch in July this year, BMC Medicine's article collection on Translational Oncology has attracted interesting research articles. Here, we present a brief overview of the most recent publications on adoptive immunotherapy for bladder cancer, tumor-associated macrophages in classical Hodgkin lymphoma, correlating tumor mutation load with immunotherapy outcomes and spatial transcriptome analysis of glioblastoma.
Tumor heterogeneity is observed at many levels: from cancer subclones in primary tumor with distinct characteristics to differences between primary and metastatic tumors in the same individual. As it affects treatment response, it is one of the key challenges in effective cancer management in the clinical practice. Here, co-authors of an article published in BMC Medicine discuss their study of kidney cancer patients.
Table of Contents Commentary
Correspondence
Editorial
Forum
Guideline
Opinion
| Vascular depression consensus report – a critical update | Howard J. Aizenstein, Andrius Baskys, Maura Boldrini, Meryl A. Butters, Breno S. Diniz, Manoj Kumar Jaiswal, Kurt A. Jellinger, Lev S. Kruglov, Ivan A. Meshandin, Milija D. Mijajlovic, Guenter Niklewski, Sarah Pospos...
BMC Medicine 2016, 14:161 |
Research | The emerging threat of pre-extensively drug-resistant tuberculosis in West Africa: preparing for large-scale tuberculosis research and drug resistance surveillance | Florian Gehre, Jacob Otu, Lindsay Kendall, Audrey Forson, Awewura Kwara, Samuel Kudzawu, Aderemi O. Kehinde, Oludele Adebiyi, Kayode Salako, Ignatius Baldeh, Aisha Jallow, Mamadou Jallow, Anoumou Dagnra...
BMC Medicine 2016, 14:160 |
| Renal function estimation and Cockcroft–Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart 'OMics' in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives | João Pedro Ferreira, Nicolas Girerd, Pierpaolo Pellicori, Kevin Duarte, Sophie Girerd, Marc A. Pfeffer, John J. V. McMurray, Bertram Pitt, Kenneth Dickstein, Lotte Jacobs, Jan A. Staessen, Javed Butler, Roberto Latini, Serge Masson...
BMC Medicine 2016, 14:181 |
| Heterogeneous response and progression patterns reveal phenotypic heterogeneity of tyrosine kinase inhibitor response in metastatic renal cell carcinoma | Shanthini M. Crusz, Yen Zhi Tang, Shah-Jalal Sarker, Warner Prevoo, Irfan Kiyani, Luis Beltran, John Peters, Anju Sahdev, Axel Bex, Thomas Powles and Marco Gerlinger
BMC Medicine 2016, 14:185 |
| MEN1 redefined, a clinical comparison of mutation-positive and mutation-negative patients | Joanne M. de Laat, Rob B. van der Luijt, Carolina R. C. Pieterman, Maria P. Oostveen, Ad R. Hermus, Olaf M. Dekkers, Wouter W. de Herder, Anouk N. van der Horst-Schrivers, Madeleine L. Drent, Peter H. Bisschop...
BMC Medicine 2016, 14:182 |
| Modelling the effect of short-course multidrug-resistant tuberculosis treatment in Karakalpakstan, Uzbekistan | James M. Trauer, Jay Achar, Nargiza Parpieva, Atadjan Khamraev, Justin T. Denholm, Dennis Falzon, Ernesto Jaramillo, Anita Mesic, Philipp du Cros and Emma S. McBryde
BMC Medicine 2016, 14:187 |
| Physical multimorbidity and psychosis: comprehensive cross sectional analysis including 242,952 people across 48 low- and middle-income countries | Brendon Stubbs, Ai Koyanagi, Nicola Veronese, Davy Vancampfort, Marco Solmi, Fiona Gaughran, André F. Carvalho, John Lally, Alex J. Mitchell, James Mugisha and Christoph U. Correll
BMC Medicine 2016, 14:189 |
| Impact of a web-based tool (WebCONSORT) to improve the reporting of randomised trials: results of a randomised controlled trial | Sally Hopewell, Isabelle Boutron, Douglas G. Altman, Ginny Barbour, David Moher, Victor Montori, David Schriger, Jonathan Cook, Stephen Gerry, Omar Omar, Peter Dutton, Corran Roberts, Eleni Frangou, Lei Clifton...
BMC Medicine 2016, 14:199 |
Review
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