| Dear Dr Wirawan,
We are pleased to share with you our April content update, featuring journal news, top articles and our most recent table of contents. Featured Collection The human microbiome is responsible for a host of functions that influence the body in both health and disease, and there is growing consensus that the microbiome is a major player in the gut-brain axis, treatment outcomes and immune responses. In this article collection, guest edited by Omry Koren, we explore some of the most recent and exciting findings in microbiome research. From the BMC Medicine blog | | Research published in BMC Medicine looks at how the age of cancer risk is lower for those that are smokers compared to non-smokers. Co-author Jose M. Ordonez-Mena explains more here. | | | Recently, Boston welcomed over 9,000 delegates from all over the world, attending ENDO 2016. Here, the BMC Medicine team highlight some of the most innovative developments discussed at the meeting. | Table of Contents Commentary Opinion Research Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort | Carolina Bonilla, Sarah J. Lewis, Richard M. Martin, Jenny L. Donovan, Freddie C. Hamdy, David E. Neal, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G. Giles, Fredrik Wiklund, Henrik Gronberg and Christopher A. Haiman | BMC Medicine 2016 14:66 | Quantification of the smoking-associated cancer risk with rate advancement periods: meta-analysis of individual participant data from cohorts of the CHANCES consortium | José Manuel Ordóñez-Mena, Ben Schöttker, Ute Mons, Mazda Jenab, Heinz Freisling, Bas Bueno-de-Mesquita, Mark G. O'Doherty, Angela Scott, Frank Kee, Bruno H. Stricker, Albert Hofman, Catherine E. de Keyser, Rikje Ruiter, Stefan Söderberg, Pekka Jousilahti and Kari Kuulasmaa | BMC Medicine 2016 14:62 | Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy | Isobella Honeyborne, Timothy D. McHugh, Iitu Kuittinen, Anna Cichonska, Dimitrios Evangelopoulos, Katharina Ronacher, Paul D. van Helden, Stephen H. Gillespie, Delmiro Fernandez-Reyes, Gerhard Walzl, Juho Rousu, Philip D. Butcher and Simon J. Waddell | BMC Medicine 2016 14:68 | Review Benefits of Publishing With Us • | 2015 median turnover times: initial decision three days; first decision after peer review 40 days | • | Portable peer review | • | Broad medical readership | Follow @BMCMedicine on Twitter | | | |