| Dear Dr Wirawan,
BMC Medicine is pleased to share with you our March content update, featuring journal news, top articles and our most recent table of contents. Featured Article Immune checkpoint inhibitors have proven to be viable therapeutic options for advanced non-small cell lung cancer (NSCLC) resistant to the standard chemotherapy with platinum-based compounds. Success in the second-line setting has encouraged evaluation of immunotherapeutics as the first-line treatment. Jordi Remon, Benjamin Besse and Jean-Charles Soria discuss contradictory results of recent phase III trials assessing first-line immunotherapy in NSCLC, looking at reasons for discrepancy and remaining open questions. From the BMC Medicine blog | | Attention disorders are prevalent in 5% of the total population and are commonly diagnosed on the basis of a patient's clinical history and an examination aided by symptom check sheets. A new study published in BMC Medicine finds that EEGs (electroencephalograms) can reliably detect specific brain differences associated with attentional disorders that are not observed in control subjects. Here to tell us more is lead author of the study, Frank Duffy. | | | Over the past few decades the concept and application of self management of asthma have evolved, reducing both emergency service use and the day to day symptoms of asthma. In this blog, authors of a new review in BMC Medicine, talk us through the history of self management and the positive evidence supporting it. | | | With the abundance of new findings on the effects of various foods on our health, how shall we select the best quality evidence and recommendations to follow? Here, we summarize recent studies published in BMC Medicine, which provide evidence on the effects of various nutritional modifications on health outcomes. | Table of Contents Commentary Debate Minireview Opinion Research Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome | Xinyi Lin, Ives Yubin Lim, Yonghui Wu, Ai Ling Teh, Li Chen, Izzuddin M. Aris, Shu E. Soh, Mya Thway Tint, Julia L. MacIsaac, Alexander M. Morin, Fabian Yap, Kok Hian Tan, Seang Mei Saw, Michael S. Kobor… BMC Medicine 2017 15:50 | Are potentially clinically meaningful benefits misinterpreted in cardiovascular randomized trials? A systematic examination of statistical significance, clinical significance, and authors' conclusions | G. Michael Allan, Caitlin R. Finley, James McCormack, Vivek Kumar, Simon Kwong, Emelie Braschi, Christina Korownyk, Michael R. Kolber, Adriennne J. Lindblad, Oksana Babenko and Scott Garrison BMC Medicine 2017 15:58 | Can incontinence be cured? A systematic review of cure rates | Rob Riemsma, Suzanne Hagen, Ruth Kirschner-Hermanns, Christine Norton, Helle Wijk, Karl-Erik Andersson, Christopher Chapple, Julian Spinks, Adrian Wagg, Edward Hutt, Kate Misso, Sohan Deshpande… BMC Medicine 2017 15:63 | The effect of intervening hospitalizations on the benefit of structured physical activity in promoting independent mobility among community-living older persons: secondary analysis of a randomized controlled trial | Thomas M. Gill, Daniel P. Beavers, Jack M. Guralnik, Marco Pahor, Roger A. Fielding, Michelle Hauser, Todd M. Manini, Anthony P. Marsh, Mary M. McDermott, Anne B. Newman, Heather G. Allore & Michael E. Miller BMC Medicine 2017 15:65 | Prediction of complications in early-onset pre-eclampsia (PREP): development and external multinational validation of prognostic models | Shakila Thangaratinam, John Allotey, Nadine Marlin, Julie Dodds, Fiona Cheong-See, Peter von Dadelszen, Wessel Ganzevoort, Joost Akkermans, Sally Kerry, Ben W. Mol, Karl G.M. Moons, Richard D. Riley & Khalid S. Khan BMC Medicine 2017 15:68 | Review Benefits of publishing with us • | 2016 median turnover times: initial decision three days; first decision after peer review 40 days | • | Portable peer review | • | Broad medical readership | Follow @BMCMedicine on Twitter | |